49ers To Open S Talanoa Hufanga’s Practice Window, Place RB Jordan Mason On IR

As injuries once again define a 49ers NFC title defense, the team still has some silver linings in the form of defenders reentering the equation. Talanoa Hufanga is on his way back.

Down with a wrist injury for months, Hufanga is set to practice this week, Kyle Shanahan said. After rehabbing the ACL tear sustained on Thanksgiving night last year, Hufanga suffered a significant wrist malady that limited him to just two games thus far this season. The 49ers, however, had not ruled him out. Now in the IR-return window, the All-Pro safety has three weeks to return.

With Hufanga joining Dre Greenlaw in a return window from an injured list, Jordan Mason is heading to IR. The Christian McCaffrey backup suffered a high ankle sprain Sunday night, NFL.com’s Ian Rapoport tweets. The 49ers lost McCaffrey to another injury — a PCL issue — that is expected to shut him down. Mason is now out until at least Week 18, leaving rookie Isaac Guerendo as the 49ers’ lead back for the foreseeable future.

Hufanga, who is in a contract year, will not be 100% if he returns to action. Shanahan said (via the Bay Area News Group’s Cam Inman) the standout DB still needs support for his injured wrist. With a potential free agency run coming, Hufanga will attempt to give it a go. Counting last season’s three playoff games, the former fifth-round pick has missed 20 of the 49ers’ past 22 contests.

Conflicting reports emerged earlier this season about whether Hufanga would return. An October offering suggested the 49ers were not counting on him to return, but the team had not ruled it out. San Francisco will at least see how he looks in practice. The injuries to Hufanga and Greenlaw played a key role in the 49ers falling just short in an overtime Super Bowl loss last season; for the first time since Hufanga’s November 2023 ACL injury, both will be back at work. Though, this comes at a dire point for a team in one of the worst Super Bowl hangovers in recent memory. A three-game losing streak has dropped the 49ers to 5-7.

The 49ers already played without All-Pros Nick Bosa, Trent Williams and Brandon Aiyuk on Sunday night. All-Pro linebacker Fred Warner, who is playing through an ankle fracture, left the game as well. Recently extended cornerback starter Deommodore Lenoir missed Week 13, while Brock Purdy returned after missing Week 12 due to injury. McCaffrey joins Mason in heading to IR, and Shanahan said defensive tackle Kevin Givens suffered a pectoral tear and will join the RBs on the injured list.

Beating out Elijah Mitchell for the backup running back job, Mason became a vital piece for the 49ers during McCaffrey’s Achilles rehab. The former UDFA held the NFL rushing lead for a short span this season, producing three 100-yard games over his first four. He paces the 49ers with 789 rushing yards and three TDs. Mason can be retained beyond this season, as the Georgia Tech alum is eligible for restricted free agency next year. Mitchell is on season-ending IR.

He of a sub-4.4-second 40-yard dash at this year’s Combine, Guerendo has shown flashes as a Mason backup. The third-round pick is the only healthy back on San Francisco’s 53-man roster right now, a situation that will see changes made soon. Patrick Taylor is the only RB on the team’s practice squad.

Givens has been with the 49ers for six seasons, working as a rotational player for most of that time. He has a career-high 3.5 sacks this season but will join DT Javon Hargrave among the expanding 49ers’ IR contingent. Playing out a $2MM deal, Givens is among the many 49ers defenders headed toward free agency.

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