The Rams have placed cornerbacks Jalen Ramsey and Dont’e Deayon , along with tight end Tyler Higbee on the COVID-19 reserve list, per a club announcement. As well, Robert Rochell has been placed on Injured Reserve. With that, all four players will be ineligible for tonight’s marquee matchup against the Cardinals. 
The Cardinals can effectively lock up the NFC West crown with a win tonight, leaving the Rams to jockey for Wild Card placement. If Arizona was to complete the season sweep of L.A., they would remain atop the NFC at 11-2, while the loss would drop the Rams to 8-5.
Ramsey’s absence is a huge loss for a secondary that will be facing a Cardinals attack which has recently gotten back to full strength with a healthy Kyler Murray and DeAndre Hopkins. Ramsey has 59 tackles and three interception in 2021. Without him, Darious Williams will be forced into an even heavier workload, as will David Long Jr., as the Rams’ cornerback room is suddenly dangerously thin.
Offensively, the loss of Higbee will be felt in the Rams’ passing attack. He had produced 44 receptions for 395 yards and three touchdowns so far this year. Already without wide receiver Robert Woods for the remainder of 2021, even more snaps and targets will likely be coming the way of recently-acquired Odell Beckham Jr. along with sophomore Van Jefferson.
The Cardinals won the first matchup of the season, 37-20, in Week 4. Even more than initially thought, Beckham along with Von Miller – both of whom were acquired after that game – will be counted on for the Rams.