Bills running back LeSean McCoy is not playing this Sunday and could miss more time after that depending on how he heals, a source tells Josina Anderson of ESPN.com (on Twitter). 
McCoy has been having a strong season for Buffalo, averaging 5.6 yards per carry through six games. Shady also has six touchdowns and one receiving touchdown, making him one of the NFL’s most productive running backs so far in this young season. Losing McCoy will hurt Buffalo, though they do have a talented backup in Mike Gillislee.
Gillislee is expected to start when the Bills face the Dolphins on Monday. Buffalo may also make a move to add another tailback to the roster.
Last year, racked up 1,187 total yards from scrimmage in 12 games. When he was out, Karlos Williams stepped up and kept Buffalo’s ground game moving. With any luck, the Bills can stay afloat with Gillislee, Jonathan Williams, and Reggie Bush in the backfield if McCoy has to miss significant time.
Karlos Williams is in great shape, he has proven while on the Pittsburg Steelers practice team that he belongs in the starting line up of a NFL team..