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Cardinals To Place QB Kyler Murray On IR

By Sam Robinson | at November 7, 2025 12:46 pm

NOVEMBER 7: Cardinals general manager Monti Ossenfort said (via Urban) he expects Murray to return this season. Whether or not he will reclaim the starting gig even if healthy is another matter, of course, and on that front Ossenfort added “a lot can happen” between now and when a decision may be required.

NOVEMBER 5: Headlines emerged Tuesday when Jonathan Gannon praised his team’s offensive direction under backup Jacoby Brissett, who will start in Week 10. But the Cardinals will have Brissett at the controls for much longer than expected.

Kyler Murray is heading to IR with his mid-foot sprain, NFL.com’s Ian Rapoport reports. This will sideline the Arizona starter for at least four games. It comes after some new information, per Gannon, who said (via AZCardinals.com’s Darren Urban) he viewed Murray as having a chance to return in Week 10 previously.

The timing here is interesting, as Murray has been battling this injury since suffering it during the Cardinals’ Week 5 game. Gannon announced Murray was expected to return Monday night, but by Saturday, the team changed course and ruled him out. Tuesday morning, the third-year HC said nothing had changed with regard to the Cards’ QB depth chart. By Tuesday afternoon, Brissett was named the Week 10 starter — even if Murray could have dressed for the game.

Gannon was careful not to deem Murray benched when speaking Tuesday, as he pointed to the dual-threat passer needing to return to full strength. He repeated that today. Still, the Cards were seemingly ready to have Murray back for their Cowboys matchup. Days later, Brissett will be confirmed — barring injury — to end up starting for a sizable chunk of Arizona’s season. Brissett, 32, is tied to a two-year, $12.5MM deal.

Tuesday’s Murray update also brought a four- to eight-week return timetable. By placing him on IR, the Cardinals are veering toward the longer end of that recovery stretch. Surgery is not believed to be a consideration, but the former No. 1 overall pick’s rehab timeline will be extensive now that the IR move will be executed.

This will be the second IR stay of Murray’s career. He landed there in December 2022 because of the ACL tear he suffered. By the time he returned to action — midway through the 2023 season — the Cardinals had cleaned house, firing Kliff Kingsbury and GM Steve Keim. The Gannon-Monti Ossenfort duo, however, consistently praised Murray — chosen in Kingsbury’s first draft alongside Keim — and has stuck by him throughout its tenure. Murray, though, has not recaptured his Pro Bowl form from the Kingsbury years. This has led to speculation a Cards-Murray separation is coming in 2026.

Gannon’s praise for Brissett is certainly not unwarranted. As was the case during his 2022 Browns stopover, Brissett has run the offense better than the starter. Current Cardinals OC Drew Petzing was the Browns’ QBs coach while Brissett held the job during Deshaun Watson‘s suspension.

While Brissett has enjoyed an up-and-down career, five teams have asked him to be their starter — though, all of these assignments have been due to injuries or as a bridge option (for Drake Maye last season). Brissett is averaging 7.7 yards per attempt to Murray’s 6.0 this season, and the Cardinals are averaging 25.6 points per game under Brissett compared to 21.6 with Murray. This is still a small sample size, but Brissett’s 11-game sample under Petzing in 2022 did make him familiar with the offense coming into this season.

From a short- and long-term perspective, Brissett’s play over the next month will be interesting. While a Geno Smith/Baker Mayfield/Sam Darnold/Daniel Jones-like arc will be a bit difficult to envision here, Brissett faring well would give Gannon a decision to make when Murray returns to full strength.

Murray, 28, secured $32.84MM guaranteed of his $42.84MM 2026 compensation by remaining on Arizona’s roster back in March. If the Cardinals were to arrange a trade, Murray would count less than $18MM on their 2026 cap sheet. That could well become a front-burner conversation near season’s end, but for now, Murray will continue his rehab while on IR.