Jameis Winston‘s debut as the Saints’ starting quarterback will come without another of his top wide receivers. Tre’Quan Smith will begin the season on IR, Nick Underhill of NewOrleans.football tweets.

The Saints added Smith to their injury report Thursday, and the hamstring injury the fourth-year wideout has battled will shelve him for at least three games. Additionally, New Orleans placed veteran cornerback Ken Crawley on IR. Crawley is also dealing with a hamstring malady.

This injury has dogged Smith for several weeks. He has now tried and failed to come back from it twice. It caused the former third-round pick to miss extensive training camp time. It also comes, of course, at a key point for New Orleans’ passing attack, which will feature a new quarterback for the first time in 15 years. Michael Thomas‘ belated offseason ankle surgery will sideline him for at least the season’s first six games; the All-Pro is on the Saints’ reserve/PUP list.

Crawley represents key depth for a Saints team that has been undermanned at corner this year. The team traded for Bradley Roby earlier this week, however. That acquisition, pairing Roby with fellow ex-Ohio State standout Marshon Lattimore, looms larger now.

Thomas and Smith’s absences will leave Drew Brees‘ successor with a much lower-profile receiving corps. Although Marquez Callaway impressed throughout the Saints’ summer work, the team did not draft a wideout this year and has only return man Deonte Harris, third-year UDFA Lil’Jordan Humphrey and veteran Chris Hogan — who recently left the game to give lacrosse another try — at the position. Running back/wideout Ty Montgomery remains on New Orleans’ roster, and Kevin White resides on the team’s practice squad.